Expression of pro-opiomelanocortin mRNA in the hypothalamic arcuate nucleus in young and senile rats / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 481-483, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410386
ABSTRACT
Objective:
To observe the level of pro-opiomelanocortin (POMC) mRNA expression in the hypothalamic arcuate nucleus in young and senile rats.Methods:
POMC mRNA was determined with in situ hybridization, the hybridization signals and areas of POMC mRNA-positive cells were measured with computer image analysis system.Results:
Compared with young rats, average gray values of POMC mRNA-positive neurons in the hypothalalmic arcuate nucleus and near region in the senile rats decreased, but the numbers of POMC mRNA-positive neurons did not change significantly.Conclusion:
The decrease of POMC mRNA expression level in individual neurons in hypothalamic arcuate nucleus of senile rats is one of the causes that decrease the expression of peptides-derived from POMC gene.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
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