Pharmacokinetics of diclofenac sodium microemulsion in human / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 364-366, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410481
ABSTRACT
Objective:
To study the pharmacokinetics of diclofenac sodium microemulsions in human.Methods:
According to the crossover design, each volunteer was orally given diclofenac sodium microemulsion and diclofenac sodium tablet. The serum concentrations were determined by RP-HPLC with UV-detector. The concentration-time data were analyzed using 3P87 Pharmacokinetic Program and the pharmacokinetics parameters were compared by paired t-test.Results:
It was found that diclofenac sodium in serum was linear within the range of 50-8 000 μg/L. The minimum detection concentration was 30 μg/L. The mean rate of recovery was (100.55±1.56)%. After a single oral dose, AUC0~∞ were 5.563,7.891 μg*h/ml, MRT 5.489, 5.387 h for dispersible diclofenac sodium microemulsion and tablet respectively.Conclusion:
Absorption progress of diclofenac sodium microemulsion in human may be special.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
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