Distribution and Pharmacokinetics of Lung Targeting Etoposide- bovine Serum Albumin- microspheres in Mice / 中国药房
China Pharmacy
;
(12): 265-266, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410506
ABSTRACT
OBJECTIVE: To prepare etoposide- bovine serum albumin- microspheres (VP- BSA- MS)and to study the distribution and pharmacokinetics of VP- BSA- MS in mice. METHODS:
The drug concentrations in various tissues were determined by high- performance liquid chromatograph (HPLC).RESULTS:
The VP- BSA- MS was injected into mice and (47.88± 2.56 )% of the total dosage was detected in lung tissue 15min after administration, the pharmacokinetical equation was C=149.0 897e- 1.7 780t+ 3.9 627e- 0.0 398t — 153.0 524e- 3.5 054t. CONCLUSION: The VP- BSA- MS showed remakable targeting action to the lung and the pharmacokinetic regularity could be discribed as two- compartment model
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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