Experimental study on the dose-response relation of myocardial protection:hyperpolarized cardioplegic arrest with nicorandil / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 139-142, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410614
ABSTRACT
Objectives:
Dose-response effect of nicorandil cardioplegia at various concentrations was studied to optimize its myocardial protective effect.Methods:
Forty-eight isolated working rat hearts were divided into 6 groups randomly.They were group Acontrol (depolarized cardiac arrest with St.Thomas solution No.2),group B,C,E,F and Ghyperpolarized cardiac arrest (nicorandil concentration were 25,50,100,125 and 150μmol/L respectively).The hearts underwent a 120-minute hypothermic arrest (15±1)℃ with cardioplegia (40 ml/kg) and reinfused with cardioplegia (40 ml/kg) at interval of 30 minutes.Mechanical arrest time,cardiac functional recoveries,myocardial content of malondialdehyde (MDA) and ultrastructure were measured.Results:
The protective effect of nicorandil cardioplegia was dose-related.Conclusions:
The optimal concentration of nicorandil in cardiplegia may be 100μmol/L for myocardial protection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2001
Type:
Article
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