In vitro and in vivo studies on pulsatile release ta blets of diltiazem hydrochloride of the erosion-dispersion type / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
; (6): 224-227, 2001.
Article
in Zh
| WPRIM
| ID: wpr-410695
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ABSTRACT
Objective: To investigate the preparation of pulsatile release tablets, the release of the drug in vitro and the pharmacokinetics in vivo . Methods: Dil tiazem hydrochloride(DIL) was used as model drug. The pulsatile release tabl e ts were prepared by dry-coated method with carnauba wax, bee wax and hydrophil i c cellulose as coating materials. The effects of formulation and technology on t he release characteri stic of diltiazem hydrochloride was investigated. The mechanism of pulsatile rel ease of the drug was proved by erosion test. The pharmacokinetic study on four h uman subjects was done by means of HPLC measurement. Results: In vitro , delayed-release ti me t 10 was 2.1 h, the maximum release time t rm 4.0 h and t he pulsed-releas e time t 10-90 1.7 h. In vivo , delayed-release time t la g was 5.7 h, the p eak time 8.5 h and the pulsed-release time 2.6 h. Conclusion: The rele ase of drug from pulsatile-released tablets of diltiazem hydrochloride was in a pulsed way both in vitro and in vivo .
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Language:
Zh
Journal:
Journal of Peking University(Health Sciences)
Year:
2001
Type:
Article