Alternation of CEA levels in nude mice with liver metastases from colon cancer treated with 131I-labeled anti-CEA monoclonal antibody / 中国普通外科杂志

ABSTRACT

Objective　To investigate the changes of CEA levels of blood, ascites and cancer tissue in nude mice with liver metastases from colon adenocarcinoma treated by 131I-labeled anti-CEA monoclonal antibody (McAb). Methods　131I-labeled anti-CEA McAb was injected through tail vein at 10min(early treatment group), 10d(middle treatment group) and 20d(late treatment group) after the liver metastases were established respectively. 131I-labeled anti-normal mice IgG was injected through tail vein after the liver metastatic model was estabished as a control group. Results　The CEA levels of blood, ascites and cancer tissue in early treatment group were significantly decreased compared with the control group (P<0.01); but, there was no difference between the early treatment group and the late treament group (P>0.05). Conclusions　The CEA levels of blood, ascites and cancer nodulus in nude mice with liver metastases from colon cancer could be lowered significantly when the 131I-labeled anti-CEA McAb is used early after the liver metastasis is established.