Fluvastatin vs pravastatin in treating hyperlipidemia / 中国新药与临床杂志

ABSTRACT

AIM: To observe and compare the antihyperlipidemia efficacy of fluvastatin vs pravasatin. METHODS: Fluvastatin group(n=41,M 22, F 19; age 60 a±s 8 a) was treated with fluvastatin 20-40 mg, po, qn for 4 wk. Pravastatin group(n=35, M 20, F 15; age 60 a±6 a) was treated with pravastatin 10 mg, po, qn for 4 wk. RESULTS: The total effective rate of fluvastatin for reducing TC was 92 %, it was higher than that of pravastatin 70 %(P＜0.05). The total effective rates of flavastatin for reducing TG and raising HDL-C were 61 % and 61 %, were similar to that of pravastatin 73 % and 69 %(P＞0.05). Adverse reactions occurred in 8 patients of fluvastatin(20 %) and in 7 patients of pravastatin(20 %), but were mild in both groups. CONCLUSION: Fluvastatin is a safe and effective antihyperlipidemic drug, and fluvastatin is more effective than pravastatin in decreasing total cholesterol.