Your browser doesn't support javascript.
loading
Determination of relative bioavailability of anastrozole in healthy volunteers / 中国新药与临床杂志
Chinese Journal of New Drugs and Clinical Remedies ; (12): 159-162, 2001.
Article in Chinese | WPRIM | ID: wpr-410983
ABSTRACT

AIM:

To evaluate the bioequivalence of domestic and imported anastrozole tablet.  

METHODS:

According to the crossover design, each volunteer was orally given anastrozole tablets (1 mg). GC determined the drug concertrations in plasma. The linear ranges was from 0.5 to 200.0 μg*L-1 plasma (r=0.9997, n=9). The recovery rates of lower, mid, higher concentration (1.0,10.0,20.0 μg*L-1 plasma were 93.50 %, 100.17 %,98.96 % respectively. Inter-day and intra-day precisions of the method were <13 %.  

RESULTS:

The pharmacokinetic parameters of the domestic and imported tablet were 1.2 h±0.5 h and 1.3 h±0.4 h for T max, 10 μg*L-1±3 μg*L-1 and 10.2 μg*L-1±2.5 μg*L-1 for Cmax, 386 μg*L-1±117 μg*L-1 and 385 μg*L-1±117 μg*h-1*L-1 for AUC0-T,36 h±14 h and 32 h±10 h for T1/2 respectively. The relative bioavailability of the domestic tablet was (100±9) %.  

CONCLUSION:

Domestic and imported anastrozole tablet are bioequivalence in healthy volunteers.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of New Drugs and Clinical Remedies Year: 2001 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of New Drugs and Clinical Remedies Year: 2001 Type: Article