Determination of relative bioavailability of anastrozole in healthy volunteers / 中国新药与临床杂志
Chinese Journal of New Drugs and Clinical Remedies
;
(12): 159-162, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410983
ABSTRACT
AIM:
To evaluate the bioequivalence of domestic and imported anastrozole tablet.METHODS:
According to the crossover design, each volunteer was orally given anastrozole tablets (1 mg). GC determined the drug concertrations in plasma. The linear ranges was from 0.5 to 200.0 μg*L-1 plasma (r=0.9997, n=9). The recovery rates of lower, mid, higher concentration (1.0,10.0,20.0 μg*L-1 plasma were 93.50 %, 100.17 %,98.96 % respectively. Inter-day and intra-day precisions of the method were <13 %.RESULTS:
The pharmacokinetic parameters of the domestic and imported tablet were 1.2 h±0.5 h and 1.3 h±0.4 h for T max, 10 μg*L-1±3 μg*L-1 and 10.2 μg*L-1±2.5 μg*L-1 for Cmax, 386 μg*L-1±117 μg*L-1 and 385 μg*L-1±117 μg*h-1*L-1 for AUC0-T,36 h±14 h and 32 h±10 h for T1/2 respectively. The relative bioavailability of the domestic tablet was (100±9) %.CONCLUSION:
Domestic and imported anastrozole tablet are bioequivalence in healthy volunteers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of New Drugs and Clinical Remedies
Year:
2001
Type:
Article
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