Effect of X-rays on the expression of B7-1 and B7-2 in per itoneal macrophages / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition)
;
(6): 111-113, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411033
ABSTRACT
Objective:
The effect of whole body irradiation (WBI) on B7-1 and B7-2 express ion in peritoneal macrophages in mice was observed.Methods:
Immunohistochemistry (ABC method) was used.Results:
The upregulation of B7-2 expression induced by WBI X-rays appeared ea r lier than that of B7-1.The study on the dose-effect relationship showed that t he ex pression of both B7-1 and B7-2 reached its peak at 0.075 Gy after WBI X-rays. Th e doses inducing a second peak of B7-1 and B7-2 upregulation were higher in th e case of WBI in comparison with in vitro irradiation.Conclusion:
The results suggested that the upregulation of expression of B7 mole cules after irradiation might be an important factor involved in the enhancing e ffect of low dose radiation on immunity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Jilin University(Medicine Edition)
Year:
2001
Type:
Article
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