Time-dependent change in expression of type-Ⅰ collagen protein gene during the development of restenosis after arterial injury / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 133-137, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411129
ABSTRACT
Objective:
To observe the alteration of type- Ⅰ collagen protein gene expression after arterial injury and investigate its effect on the development of restenosis.Methods:
Firstly, thee xperimental carotid arterial injury rabbit model was constructed. Then, Norther n blot, in situ hybridization and histomorphometric analysis were used to de tect the expression of procollagen mRNA and the accumulation of collagen protein 1,2,4 weeks after injury.Results:
Type- Ⅰ collag en mRNA increased 1 week after injury, peaked 2 weeks later and decreased 4 week s later. The deposition of the collagen protein account for a high percentage o f space in neointima on histomorphometric analysis.Conclusion:
Collagen protein may play an important role in the development of neointima and restenosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS