PREDICTING SKIN PERMEABILITY OF DRUGS WITH THEORETICAL PARAMETERS / 药学学报
Acta Pharmaceutica Sinica
;
(12): 145-147, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411313
ABSTRACT
AIM To predict skin permeability of drugs with theoretical parameters. METHODS The semiempirical self-consistent field molecular calculation AM1 method is utilized to obtain the structural parameters of drug molecules. Stepwise multiple regression analysis or BP neural network is then utilized to establish the correlation between skin permeability of drugs and their structural parameters. RESULTS The calculated human skin permeability coefficients (kp) of 22 model drugs in vitro or the R values (R=absorbed/unabsorbed) of 17 drugs in vivo are in good agreement with their observed values. CONCLUSION Theoretical parameters can be used to predict skin permeability of drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2001
Type:
Article
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