ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBIT / 药学学报
Acta Pharmaceutica Sinica
;
(12): 137-139, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411315
ABSTRACT
AIM To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in the rabbit. METHODS Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2001
Type:
Article
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