Hepatic artery and portal vein dual perfusion chemotherapy combined with intratumoral injection of lipiodol-ethanol for unresec-table primary hepatic carcinoma / 中国普通外科杂志

ABSTRACT

Objective　To study the therapeutic effect of hepatic artery and portal vein dual perfusion chemotherapy (AVPC) combined with intratumoral injection of lipiodol-ethanol (ITILE) for unresectable primary hepatic carcinoma (PHC). Methods　138 pathologically proved and unresectable PHC cases were divided into two groups Group A (80 cases), treated with AVPC through hypodermic implanted drug delivery pumps. Group B (58 cases), treated with AVPC plus ITILE. Results　　The secondary resection rate was 2.5% in group A, while 　 12.1% in group B, (P<0.05); The 0.5, 1, 2 years survival rate in group A was 56.3% 45.0% and 21.2%, in group B 81.0% 61.2% and 39.6% respectively. there were significent difference between two groups in 0.5,1,2 years survival rate respectively (P<0.05); the complication occurrence rate was found no significant difference between two groups (P>0.05). Conclusions　The therapeutic effect of AVPC plus ITILE for unresectable PHC is much better than that of AVPC alone.