Effects of genistein on the proliferation of cardiac fibroblasts / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 159-160, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411469
ABSTRACT
To study the effect of genistein on the proliferation of cardiac fibroblasts(CF), CFs were cultured from neonatal rat hearts, DNA synthesis of the cells was determined by incorporation of [3H]TdR into DNA, the cell cycle was measured by flow cytometric analysis. Genistein(0.5-50 μmol*L-1) attenuated 2.5% fetal calf serum-induced proliferation of CF in concentration-dependent manner. Genistein(50 μmol*L-1) arrested CF cell progression at G2/M phase. The results suggest that genistein be a potential substance for treatment of cardiac fibrosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pharmacology and Toxicology
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS