The effect of bFGF on the apoptosis and its relative gene in rat brain following cerbral ischemia-reperfusion / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 208-210, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411553
ABSTRACT
AIM To study the effect of exogenous bFGF on the cell apoptosis and the expression of HSP 70 protein and p53 gene. METHODS The effect of exogenous bFGF on HSP 70 protein and gene expression was examined vial insitu hybridization and immunohistochemistry, at 0~72 h reperfusion after the middle cerebral artery (MCA) was occluded for 2 h in rats. Simutaneously, the distribution of apoptosis was observed. RESULTS The expression of HSP 70 protein elevated and the expression of p53 gene and cell apoptosis decreased in bFGF treated rats as compared with ischemia rats. (P<0.05, P<0.01). CONCLUSION Exogenous bFGF can supress the apoptosis and regulate its relative gene.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2001
Type:
Article
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