Changes in plasma endothelin-1 and atrial natrinretic factor in microvascular complication of IDDM / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition)
;
(6): 68-70, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411572
ABSTRACT
Objective:
To investigate the changes in plasma ET-1 and ANF in IDDM and its microvascular complication.Methods:
The plasma levels of ET-1 and ANF were measured by radioimmunoassy in 31 patients with IDDM and 25 normal controls.Results:
The plasma levels of ET-1 and ANF significantly increased in IDDM compared with the normal controls (P<0.01);and the levels were also markedly higher in diabetics with microangiopathy complications than in those withou the complications (P<0.01).The more kinds of microangiopathey complications,the higher level of the plasma ET-1 and ANF,which suggests that the elevation of plasma ET-1 and ANF may be concerned with the microangiopathy and ET-1 may reflect the degree of vascular endothelial cell damage.There were no significant correlation between plasma ET-1 or ANF and blood glucose,fructosamine and C-peptide,but the plasma levels of ET-1 and ANF both correlated with the duration of diabetes mellitus.And the plasma level of ET-1 positively correlated with ANF1 (P<0.01).Conclusion:
The results of study suggest that ET-1 and ANF are both associated with the development,progress and severity of microvascular complications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Jilin University(Medicine Edition)
Year:
2001
Type:
Article
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