Study of the concentrations of interleukin\|5 in tissue and secretion of nasal polyps / 中国耳鼻咽喉头颈外科

ABSTRACT

Objective: To explore the IL\|5 values in the tissue and secretion of nasal polyp. Methods: The concentrations of IL\|5, either in tissue homogenate or in nasal secretion, were measured by ELISA. The values of total protein in tissue homogenate were measured by Bradford colorimetry. In this study, 31 cases with nasal polyp, 8 patients with perennial allergic rhinitis (PAR), 11 cases with chronic sinusitis (CS) and 6 control cases were chosen. Results: ① In tissue homogenate, the IL\|5 concentrations of nasal polyp were higher than that in CS or control group (P＜0.001). ② In nasal secretion, IL\|5 values of both nasal polyp and PAR group were significantly higher than that in CS or control group (P＜0.05). ③ When all cases or only patients with nasal polyp were taken as the subjects, the Pearson correlation coefficient were 0.70, 0.66 respectively. Conclusions: IL\|5 values, both in tissue homogenate and nasal secretion, are significantly higher, which suggested that there were a close relationship between IL\|5 and nasal polyp, and IL\|5 play a key role in the formation of nasal polyp.