Experimental Study of Effect of Aluminum on Learning and Memory and the Changes of Synaptic Interface Constructure in Hippocampus CA3 Area in Rats / 解剖科学进展
Progress of Anatomical Sciences
;
(4): 4-6, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411675
ABSTRACT
Objective To study the effect of aluminum on learning and memory and the synaptic interface constructure in hippocampus CA3 area in rats. Methods The electrical maze were used to test the behavioral reaction of rats. Some parameters of synaptic interface structure were measured by the method of ultrastructural quantitative analysis in hippocampus CA3 area in the rats. Results The time coming through the E-maze prolonged siginificantly in the experimental group compared with the normal control (P<0.01), meanwhile the cyto-apparatus demonstrated the pathogenetic changes. Amounts of synapse obviously reduced and the post-synaptic density turned thinner in experimental group than in the control group (P<0.01). Conclusion Aluminum can cause the malfunction on learning and memory, which related to the plastic of synapse.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Progress of Anatomical Sciences
Year:
2001
Type:
Article
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