Translesion Synthesis DNA Polymerase: A Novel DNA Polymerase / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics
;
(12): 656-60, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411740
ABSTRACT
although there are many repair pathways in cells, some lesions still escape repair inevitably and remain in genome. In cells, the molecular mechanism of translesion DNA synthesis has been one of the major unsolved problems in DNA repair for a long time. Recently, it was found that the members of a structurally related UmuC/DinB protein superfarnily have DNA polyrnerase function. Unlike the classical replicative DNA polymerases, these newly identified DNA polymerases can carry out translesion DNA synthesis in both error prone/mutagenic and/or error-free ways. It was also found that their functions are conserved from bacteria to human.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Progress in Biochemistry and Biophysics
Year:
2001
Type:
Article
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