Experimental mouse model of Chlamydia pneumoniae strain pneumonitis / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 6-8, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-411903
ABSTRACT
Objectives:
To evaluate mice as experimental animal for Chlamydia pneumoniae, a common cause of acute respiratory infections in human.Methods:
Intranasal inoculation of Icr mice with C. Pneumoniae induced a prolonged course of lung infection, as demonstrated by persistence of lung pathology(60 days).Results:
Icr mice were susceptible to C. pneumoniae. Lung pathology was characterized by patchy interstitial pneumonitis with predominately neutrophil leukocyte infiltration in the early(7 days) and lymphocytes infiltration in the later stages(14 days later) of infection.Conclusions:
Icr mice were susceptible to C. pneumoniae and the mouse model is useful for the investigation of the pathogenesis of C. pneumoniae infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS