Left Ventricular Hypertrophy to Heart Failure in Gradually Pressure Afterload Heart of Wistar Rat / 中国医科大学学报
Journal of China Medical University
;
(12): 9-11, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-412103
ABSTRACT
Objective:
Our purpose was to establish an ideal chronic pressure-afterload heart failure rat model which has the transition from cardiac hypertrophy to heart failure.Methods:
Chronic pressure-afterload heart failure rat model was induced by gradually constricting the ascending aorta of young rats. Young rats were randomly divided into 2 groups the constricted and sham-operated groups. Clinical manifestation, tail-cuff blood pressure, organ weight, and hemodynamic data were observed at various time after operation.Results:
The overall survival rate was 87%. Tail-cuff pressure began to increase in 4 weeks after operation. Left ventricular hypertrophy appeared in 12 weeks and heart failure in 5 months.Conclusion:
It's a practical and reproducible model of cardiac hypertrophy that progresses to chronic heart failure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Medical University
Year:
2001
Type:
Article
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