Growth hormone regulate the function of T lymphocytes / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 480-484, 2000.
Article
in Chinese
| WPRIM
| ID: wpr-412267
ABSTRACT
To study the effects of growth hormone on function of T lymphocytes. Methods:
Tne expression plasmid PcDNA-GHcDNA was constructed,then the plasmids were transfected into Jurkat cells,on the other hand,Jurkat cells were treated with different doses ofrhGH, to investigate the effect of overexpression GH and rhGH on function of T lymphocytes.Results:
Overexpression GH could increase the ex-pression of IL-2R(140%) and secretion of IL-2(160%) and IFN-γ( 198% ) in Jurkat cells after PHA activation,but these data were broughtdown by the treatment of GH antibody. rhGH could also enhancer the function of T lymphocytes after PHA activation.Conclusion:
These resultssupport the idea that GH is an autocrine and paracrine factor, and can regulate the function of T lymphocytes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2000
Type:
Article
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