Analysis of Antibodig Spectrum of Anti- membranous Lahyrinth Proteins in Experimental Animals with Autoimmune Inner- ear Disease / 听力学及言语疾病杂志
Journal of Audiology and Speech Pathology
;
(6): 131-133, 2000.
Article
in Chinese
| WPRIM
| ID: wpr-412364
ABSTRACT
ObjectiveTo define the components of membranous labyrinth proteins which take part in the development of autoimmunity in experimental animals with autoimmune inner- ear disease(AIED). MethodsAn animal modee of AIED was es tablished by using homologous crude inner ear antigen to immune the guinea pig. The autoantibodies against inner ear antigenin the sera of animals were examined by immunoblotting assay. ResultsThe components of membranous labyrinth proteins were very complicated, which had five main bands in electrophoresis; most of immunized animals had only developed two sorts of autoantibod ies which were anti-68 kD and 136 kD membranous labyrinth proteins. There was no positive reaction in sera of control animals. Conclusion This results showed that the immune reactions against the 68 kD and 136 kD proteins of membranous labyrinth may be autoimmune bases for AIED in animals.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Audiology and Speech Pathology
Year:
2000
Type:
Article
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