EFFECT OF DA ON GABA-ACTIVATED CURRENT IN RAT DRG NEURONS / 神经解剖学杂志
Chinese Journal of Neuroanatomy
;
(6): 205-208, 2000.
Article
in Chinese
| WPRIM
| ID: wpr-412378
ABSTRACT
Whole-cell patch-clamp technique was performed on isolated rat DRG neurons to investigate the modulation of DA onGABA-activated membrane currents. It was found that majority of the examined neurons(40/47) were sensitive to GABA, 10-6~ 103mol/L GABA activated a dose-dependent inward current which had an obvious desensitization. In 26 of 40 neurons sensitiveto GABA DA induced a little outward current which had no desentization at all. Others showed no effect obviously. When theneurons were treated with DA 10-7~10-4 mol/L prior to the application of GABA for 30 s, 68% (27/40) GABA-activated mem-brane currents were inhibited, whereas DA10-5 inhibited markedly(33.3%) (x±s).
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Neuroanatomy
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS