Clinical observation on topiramate combined with sodium valproate in treatment of infantile spasms / 中国基层医药

ABSTRACT

Objective To observe the clinical effects of topiramate combined with sodium valproate in treatment of infantile spasms.Methods 40 children with infantile spasms were randomly divided into control group and treatment group,each group 20 patients.The control group was treated with sodium valproate.The treatment group received topiramate combined with sodium valproate.The two groups were all treated for 3 months.Results The total effective rate and electroencephalogram improvement of the treatment group was 95.0% ,90.0% respectively,and significantly better than those of the control group ( 70.0% , 60.0% respectively ) ( x2 = 4.32,4.80, all P < 0.05 ).Conclusion The therapeutic effect of topiramate combined with sodium valproate in treatment of infantile spasms was good and worthy of being widely used in clinic.