Progress of cyclophosphamide pharmacology and therapy of maligant tumors in children / 国际儿科学杂志

ABSTRACT

Cyclophosphamide is a widely used drug in clinic,which is a non-specific cell cycle nitrogen mustard cytotoxic drug.It is mainly used in the chemotherapy of malignant tumors and autoimmune diseases.Recent studies have found that its differences of metabolism in vivo are connected with the differences of individual genetic level.Some drugs can enhance the anti-tumor effect of cyclophosphamide.There age some progress in the treatment of acute leukemia and lymphadenoma in children.