Estrogen and the longitudinal growth of bone / 国际儿科学杂志

ABSTRACT

As a system,estrogen co-plays with growth hormone affecting the longitudinal bone growth.Meanwhile.estrogen receptors(ERα,ERβ,GPR30)are also involved in the regulation of the proliferation,mature and apoptOSis of the chondrocytes in the growth plate. It is well known that ERα promotes the clogure of the growth Mate.while it's emphasized by some latest articles that it is the genetic structure of ERβ that can disturb the expression of the ERα at certain level of serum concentration of estrogen.It regulates the physiological states of the bone growth as well as explains some pathological process. Some new progresses of GPR30 in this field are also summaried in this review.