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Role of mTOR signaling pathway in the pathogenesis of pancreatic cancer / 中华胰腺病杂志
Chinese Journal of Pancreatology ; (6): 28-30, 2011.
Article in Chinese | WPRIM | ID: wpr-414421
ABSTRACT
Objectives To investigate the expression of mTOR signaling pathway in pancreatic cancer and export its signification. Methods 6 samples of pancreatic cancer and its paracancerous tissues specimens confirmed by surgery and pathologic examination were selected. RNA was extracted and expression profiles experiment was performed by using Agilent human whole genomic oligonucleotide microarrays. The expression of mTOR signaling pathway in pancreatic cancer was analyzed by bioinformatics. Results Totally 1276 differential gene were selected, and 691 were up-regulated in cancer tissue, while 585 were down-regulated.The highest score of KEGG pathway's Enrichment and gene count was hsa04150 in mTOR signaling pathway,with its Enrichment of 4.5622519 and gene count of 9, and the percentage of gene count was 1.15%, the EASE Score P value was 6.23 E-04, which had the most biological significance. Among those, there was significantly difference of expression of nine key genes including ULK2, PIK3R3, PDPK1, EIF4EBP1, PGF,VEGFB, ULK3, RICTOR and PIK3 R5 (P < 0.05). Conclusions The pathogenesis of pancreatic cancer is related to the activation of the mTOR signaling pathway.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Pancreatology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study Language: Chinese Journal: Chinese Journal of Pancreatology Year: 2011 Type: Article