Pigment epithelium-derived factor and tumor / 国际肿瘤学杂志

ABSTRACT

Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor (serpin) family, is well known for its endogenous antiangiogenic activity. The down-regulation or depletion of PEDF has been shown in many tumor tissues, and it was proved to be correlated with the prognosis of tumor. At present,the biological properties of PEDF and the mechanism of its anti-tumor activity have become a focus research, and it provides theoretical foundation to the treatment of carcinoma.