A Case of Vascular Leak Syndrome During Induction Chemotherapy of Acute Lymphoblastic Leukemia (T Cell Type)
Journal of the Korean Pediatric Society
;
: 1041-1046, 2001.
Article
in Korean
| WPRIM
| ID: wpr-41507
ABSTRACT
Vascular leak syndrome(VLS) is characterized by endothelial damage, which causes extravasation of plasma proteins and fluid from capillaries into the extravascular space. It has been suggested that the increased vascular permeability is the result of an IL-2-induced suppression of endothelin-1 secretion by endothelial cells, an IL-2-induced activation of the complement cascade or TNF-alpha release from IL-2-activated T-cells. A 13-year-old male patient visited our hospital with abdominal pain. He was diagnosed with acute lymphoblastic leukemia(T cell type) by bone marrow study on his 2 nd day in hospital. On the 3 rd day of induction chemotherapy(prednisone, L-asparaginase, vincristine, intrathecal methotrexate), pulmonary edema and pleural effusion, ascites and generalized edema developed and lasted for 53 days without responding to supportive care. The laboratoy finding was that TNF-alpha was increased without evidence of infection and hypoalbuminemia was noted. It was suggested that the patient's clinical feature was induced by VLS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pleural Effusion
/
Ascites
/
Pulmonary Edema
/
Vincristine
/
Bone Marrow
/
Complement System Proteins
/
Capillaries
/
Capillary Permeability
/
Blood Proteins
/
T-Lymphocytes
Limits:
Adolescent
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
2001
Type:
Article
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