Disulfiram Induced Psychosis
Clinical Psychopharmacology and Neuroscience
;
: 68-69, 2017.
Article
in English
| WPRIM
| ID: wpr-41575
ABSTRACT
Disulfiram is the commonly prescribed drug for the treatment of alcohol dependence. It's major metabolite (diethyldithiocarbamate) is an inhibitor of dopamine-betahydroxylase, an enzyme that catalyzes the metabolism of dopamine to norepinephrine resulting in psychosis. We recommend that disulfiram should be used at the lowest effective dose, possibly 250 mg daily and caution should be taken while prescribing disulfiram for patients with personal and familial antecedents of psychosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychotic Disorders
/
Dopamine
/
Norepinephrine
/
Disulfiram
/
Alcoholism
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2017
Type:
Article
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