Changes of HMGB1 and VE-cadherin in serum of children with viral myocarditis / 中国综合临床

ABSTRACT

Objective To investigate the changes of high mobility group box-1 ( HMGB1 ) and VE-cadherin in serum of children with viral myocarditis and their clinical significance. Methods The serum levels of HMGB1 and VE-cadherin were detected by ELISA in 52 children with viral myocarditis, and 36 normal healthy children were enrolled as control. CK-MB was also measured in all subjects enrolled into the study. Results The serum levels of HMGB1, VE-cadherin and CK-MB in children with acute stage viral myocarditis (HMGB1[5.14 ±0. 23] mg/L;VE-cadherin [5.36 ±0. 92] mg/L;CK-MB [31.42 ± 3.22] U/L)were significantly higher than those with recovery stage viral myocarditis ( HMGB1 [ 0. 92 ± 0. 14 ] mg/L, VE-cadherin [2. 93 ±0. 64] mg/L; CK-MB [ 13.75 ± 3.18 ] U/L) ( t = 11.37,10. 26 and 12. 17 respectively ,Ps ＜ 0. 01 )and control (HMGB1[ 0. 86 ± 0. 12 ] mg/L; VE-cadherin [ 2. 86 ± 0. 65 ] mg/L; CK-MB [ 12. 83 ±3.04] U/L) (t = 12.06,11.19 and 12. 64 respectively,Ps ＜0.01 ). However,we found no significant difference in the serum levels of HMGB1, VE-cadherin and CK-MB between recovery stage viral myocarditis group and the control ( t = 1.26,1.19,1.43, Ps ＞ 0. 05 ). There were positive correlations between HMGB1 and VE-cadherin,CK-MB (r = 0. 73,0. 79, Ps ＜ 0. 05 ) ;and positive correlation between VE-cadherin and CK-MB (r= 0. 82, P ＜0.05). Conclusion HMGB1 and VE-cadherin may play roles in the viral myocarditis pathogenesis, which can be new prognosis factors for viral myocarditis.