The function of hepatic oval cells under high glucose condition in vivo / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 604-606, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-416746
ABSTRACT
Rat hepatic oval cell model was induced by hyperglycemia and streptozotocin in vivo. Expression of insulin and mRNA expression of pancreatic transcription factors(Nkx6.1, PDX-1) were carried out. It showed that under high glucose, liver tissues were positive for insulin staining, the expression of Nkx6.1 and Pdx-1mRNA was significantly enhanced, and insulin-1mRNA was found to be expressed. The result suggests that under high glucose, hepatic oval cells can differentiate into insulin-producing cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2011
Type:
Article
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