Progress of study on the KAI1 gene in gynecological tumor / 肿瘤研究与临床

ABSTRACT

KAI1 is a recently identified metastasis suppressor gene located at human chromosome 11 p11.2. KAI1 protein is a member of the structurally distinct family of cell surface glycoprotein and belongs to transmembrane 4 protein superfamily. KAI1 expression is down-regulated in many metastatic tumor cells. Down-regulation of KAI1 expression also plays an important role in the genesis and development of gynecological tumor.