The study of permissive hypercapnia in the treatment of acute lung injury / 国际儿科学杂志

ABSTRACT

Mechanical ventilation can increase the survival rate of acute lung injury significantly,but the traditional ventilation can cause ventilator-induced lung injury.Permissive hypercapnia can alleviate barotrauma and volutrauma which are caused by the traditional mechanical ventilation,reduce proinflammatory or inflammatory cytokines release,decrease cell apoptosis,improve pulmonary ventilation function,regulate vascular contraction and relaxation and so on.It has a prospect in the treatment of acute lung injury.But it can suppress the immune response and alveolar epithelial repair,reduce pulmonary edema fluid absorption and other adverse effects.Those adverse effects limit clinical application of permissive hypercapnia.