Immune tolerance biomarkers in organ transplantation / 国际外科学杂志

ABSTRACT

Although the organ transplantation had a rapid development in the last 50 years due to the immunosuppression application,the side effect of the immunosppression is one factor affecting the recipient' s long term survival.Immune tolerance induction can solve this problem.Some studies had found a few operational tolerance organ recipients in clinical practice.The regulatory T cells and some gene's expression in the peripheral blood can be used as the potential immune tolerance biomarkers in the operational tolerance kidney and liver recipient.The dentritic cells,and the γδTCR + T cells' number differences were also found in the operational tolerance liver recipient,and B lymphocyte number difference was also found in the peripheral blood of the operational tolerance kidney recipient.All these markers may be the potential biomarker of immune tolerance.As the important role of MicroRNA in the immune system,it may also be the potential immune tolerance biomarker of the organ transplantation.