Treating effects of nourishing-kidnev herbs on rat models with glucocorticoid-induced osteoporosis / 国际中医中药杂志

ABSTRACT

Objective To observe the effects of nourishing-kidney herbs on rat model with glucocorticoid-induced osteoporosis.Methods 60 Wistar rats male and female half and half were randomly divided into a normal group,a model group and a nourishing-kidney group.By intramuscular injection of dexamethasone (2.5 mg/kg) twice a week to replicate osteoporosis rat model.All groups were treated for 9 weeks.Detected the BMD of femur in vitro and determined the bone metabolism marker in serum by biochemical process.Results The BMD decreased obviously (0.109± 0.007)g/cm2 and the content of TRAP in serum increased evidently (9.96± 1.15) μg/ml in the model group.In the nourishing-kidney group,the BMD was up-regulated (0.116 ± 0.007)g/cm2,and TRAP down-regulated(5.76 ± 0.85)μg/ml.Conclusion Intramuscular injection of dexamethasone can induce GIO rat model,and nourishing-kidney herbs have the effect of anti-osteoporosis.