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Thioredoxin and neoplasm metastasis / 国际肿瘤学杂志
Journal of International Oncology ; (12): 86-88, 2012.
Article in Chinese | WPRIM | ID: wpr-418094
ABSTRACT
Thioredoxin (Trx) is a class of small redox proteins which is widely found in all organisms.It acts as antioxidant by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange.Recently,thioredoxin is found to be over-expressed in many kinds of tumor,which is closely associated with tumor cell proliferation,apoptosis and cell cycle control.Trx is also found to promote the synthesis and stabilization of the HIF-1α protein.It is also related to the control of reactive oxygen species and chemoresistance of tumor cells.Trx has been proved to play an important role in promoting the metastasis of cancer,and may become a potential target for anti-metastasis of cancer.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Oncology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Oncology Year: 2012 Type: Article