Evaluation on effects of Hydroxyethyl Starch 130/0.4 combined with Sodium Aesinate Tablets in treating edema of tibiofibular fracture / 中国基层医药

ABSTRACT

ObjectiveTo observe the effect ofhydroxyethyl starch 130/0.4 combined with sodium aesinate tablets in treating edema of tibiofibular fracture(ETF).Methods105 ETF patients were randomly assigned to tow groups,the treated group ( n =55 ) was treated with hydroxyethyl starch 130/0.4 injection (20ml.kg - 1 · d - 1 ) with sodium aesinate tablet( 30mg,bid,po),while the control group (n =50) was treated with sodium aesinate for injection (20mg in 5％ GS 500ml,ivgtt,qd),observe the decrudescence time of the fracture edema.ResultsThe significant effective rate and total effective rate were 40.0％,94.5％ in treated group and 14.0％,84.0％ in control group,showing statistical significance( P ＜0.05).The decrudescence time of Ⅱ degree and Ⅲ degree edema in treated group were (5.75 ± 2.21 ),( 8.14 ± 2.49),and ( 7.09 ± 2.03 ),( 12.18 ± 3.76 ) in control group,the difference among them was significant( P ＜ 0.05 or P ＜ 0.01 ).ConclusionThe combined therapy of hydroxyethyl starch 130/0.4and sodium aesinate tablets has good clinical curating effect in treating edema of tibiofibular,and also can reduce the adverse reaction.