EMLA-ALK fusion gene in non-small cell lung cancer / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 212-214, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-418475
ABSTRACT
EML4-ALK fusion gene can improve the expression of anaplastic lymphoma kinase (ALK) protein and activate ALK inducing tumor cells proliferation and anti-apoptosis.EMLA-ALK fusion gene in nonsmall-cell lung cancer which has unique clinical and pathological features is more common in young femal,never smokers,and adenocarcinoma patients,At present,EML4-ALK fusion gene can be detected using RT-PCR,FISH and IHC.Crizotinib,an ALK inhibitor,can block the gene's signal pathway and restrain tumor's activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2012
Type:
Article
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