Efficacy and safety of ibutilide for conversion of atrial fibrillation / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 995-996, 2012.
Article
in Zh
| WPRIM
| ID: wpr-418841
Responsible library:
WPRO
ABSTRACT
ObjectiveTo evaluate the efficacy and safety of ibutilide for conversion of paroxysmal and persistent atrial fibrillation.Methods31 patients with atrial fibrillation duration less than 90 days were included into amiodrone or ibutilide group.16 patients were intravenously administer with amiodrone and 15 patients with ibutilide separately.Conversion rate,time needed to converse and adverse effects were compared between two groups.ResultsThe total conversion rate of ibutilide group was significantly higher than that of amiodrone group (66.7% vs 37.5%,x2 =1.98,P < 0.05 ).Time needed to converse was significantly shortened in ibutilide group compared with amiodrone group [ ( 31.75 ± 7.39 ) min vs ( 51.87 ± 9.26 ) min,t =3.67,P < 0.05 ].No clinical significant adverse effects were observed in ibutilide group.ConclusionIntravenous administration of ibutilide in cardioversion of paroxysmal and persistent atrial fibrillation was more safe and effective than amiodrone.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2012
Type:
Article