The expression and significance of Smad2 in cervical cancer tissue / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 972-973, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-418845
ABSTRACT
ObjectiveTo explore the expression of Smad2 in cervical carcinoma and analyze the clinical significance of Smad2.MethodsThe expression of Smad2 in normal uterus group( NE group,n =61 ) and cervical carcinoma group( CC group,n =53 ) were detected by immunohistochemistry to analyze the significance of Smad2 in the cervical carcinoma.ResultsPositive rate of expression of Smad2 protein in NE group was 39.3%,positive rate was 77.4% in CC group,statistical difference was found between the two groups(P < 0.01 ).The degree of differentiation of cervical cancer was lower,and the Smad2 positive rate was higher,well-differentiated and poorly differentiated were 52.6% and 91.2%,respectively,and the difference was statistically significante ( P < 0.01 ) ; The invasion of cancer was higher,and the Smad2-positive rate was higher ≤ 1/2 and > 1/2 were 66.7% and 91.3%,respectively,and the difference was statistically significante ( P < 0.05 ).ConclusionThe expression of Smad2 was less; Smad2 was related to depth of invasion and degree of differentiation of cervical carcinoma,which could be used as clinical diagnosis and prognostic markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2012
Type:
Article
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