The Effect of COX-2 Inhibitor on the Growth and Metastasis of Gastric Cancer Xenograft
Journal of the Korean Surgical Society
;
: 95-102, 2002.
Article
in Korean
| WPRIM
| ID: wpr-41893
ABSTRACT
PURPOSE:
Tumor invasion and metastasis are known to be extremely important factors in the prognosis of cancer patients. Although recent studies have demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in various cancers including gastric cancer, the mechanisms underlying the contribution of COX-2 to tumorigenesis and tumor promotion remain unclear.METHODS:
In order to determine the role of COX-2 in tumor growth and metastasis, we investigated COX-2 expression, apoptosis and the expression of E-cadherin, CD44v6, MMP-2 and TIMP-2 in gastric cancer xenografts treated with meloxicam (a selective COX-2 inhibitor).RESULTS:
Cells from the MKN45 gastric cancer cell line that overexpress COX-2 were inoculated subcutaneously into athymic mice. Oral administration with meloxicam reduced the tumor volume (P<0.01), induced apoptosis of cancer cells (P<0.01), suppressed the proliferation rates (P<0.01), increased the expression of E-cadhrin (P<0.05) and reduced the expression of MMP-2 and TIMP-2.CONCLUSION:
The above data showed that COX-2 inhibitors can inhibit tumor growth and suppress metastatic potential by expression of adhesion molecules and suppression of metalloproteinases, suggesting that this inhibitor can be used as an additive anti-cancer drug in cases of stomach cancer with radical resection, although further evaluation is required.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Stomach Neoplasms
/
Cadherins
/
Cell Line
/
Administration, Oral
/
Apoptosis
/
Tissue Inhibitor of Metalloproteinase-2
/
Metalloproteases
/
Tumor Burden
/
Cyclooxygenase 2
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2002
Type:
Article
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