Clinical significance of serum bone turnover indicators in diagnosis of elderly women with osteoporosis / 中国医师进修杂志

ABSTRACT

ObjectiveTo investigate the clinical significance of serum bone turnover indicators in diagnosis of elderly women with osteoporosis.MethodsOne hundred and twenty-eight cases of elderly women with osteoporosis were divided into bone loss group (46 cases),osteoporosis group (54 cases) and severe osteoporosis group(28 cases) according to degree of osteoporosis.Selected physical examination in 45 cases of elderly women as control group.Serum bone-specific alkaline phosphatase (B-ALP),osteocalcin (BGP),tartrate resistant acid phosphatase (TRACP5b) and parathyroid hormone (PTH) levels were detected using immunological method,and determination of bone mineral density (BMD).ResultsCompared with those of control group,BGP and B-ALP of bone loss group,osteoporosis group and severe osteoporosis group was significantly increased [ (25.88 ± 10.21 ),(21.59 ± 8.67 ),( 19.15 ± 7.35 ) μ g/L vs.(9.55 ± 4.05 ) μ g/L and( 181.25 ± 11.84),( 186.25 ± 15.84),( 190.38 ± 21.24) U/L vs.( 150.55 ± 10.05) U/L] (P ＜ 0.01 or ＜0.05).PTH of bone loss group and osteoporosis group was significantly higher than that of control group [ ( 63.79 ± 21.94 ),(58.89 ± 12.03 ) ng/L vs.(43.66 ± 19.66 ) ng/L ] ( P ＜ 0.05 ).B MD of osteoporosis group and severe osteoporosis group was significantly less than that of control group [ (0.64 ± 0.25 ),(0.61 ± 0.43) g/cm2 vs. (0.98 ± 0.11 ) g/cm2 ] (P ＜ 0.01 ).TRACP5b in bone loss group and severe osteoporosis group was significantly higher than that of control group [ (5.48 ± 0.98),(5.25 ± 1.06) U/L vs.(2.75 ± 1.35) U/L) ](P ＜ 0.01 or ＜ 0.05).Conclusions Serum bone turnover indicators such as B-ALP,BGP,TRACP5b and PTH are effective in auxiliary diagnosis of elderly women with osteoporosis.