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Clinical significance of plasma N-terminal pro-brain natriuretic peptide during intraoperative period in children with congenital heart disease / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine ; (36): 20-22, 2012.
Article in Chinese | WPRIM | ID: wpr-419229
ABSTRACT
Objective To explore the clinical significance of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) during intraoperative period in children with congenital heart disease (CHD).Methods Ninety-two CHD patients (CHD group) and 92 healthy controls (control group) were enrolled.For CHD patients,the level of plasma NT-proBNP was assayed preoperative and 1st,3rd and 5th day postoperation.The relationship between NT-proBNP and recovery of cardiac function after operation was analyzed.The relationship between complications and days for hospitalization was also determined.Results Before operation,the level of NT-proBNP in CHD group was significantly higher than that in control group (median231.26 ng/L vs.62.18 ng/L)(P<0.05).After operation,the level of NT-proBNP in CHD group was significantly increased at 1st day (median357.26 ng/L) (P<0.05),3rd day(median310.66 ng/L)(P<0.05 ),and decreased at 5th day (median139.37 ng/L)(P<0.05 ).The difference of LVEF preoperative and postoperative was significantly lower in high level of NT-proBNP patients(46 cases) than that in low level of NT-proBNP patients (46 cases)[ (4.61 ± 1.69)% vs.(6.31 ± 1.27)%](P<0.05).The rate of congestive heart failure and the third atrioventricular block,the days for hospitalization were higher in high level of NT-proBNP patients than those in low level of NT-proBNP patients [ 17.39% (8/46) vs.2.17% (1/46),15.22%(7/46) vs.0,(9.36 ± 1.27) d vs.(7.21 ± 1.39) d](P<0.05).Conclusion Plasma NT-proBNP is a useful marker during intraoperative period in CHD patients.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Postgraduates of Medicine Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Postgraduates of Medicine Year: 2012 Type: Article