Expression and clinical significance of urotensin Ⅱ in lung cancer tissue / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 794-796, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-419482
ABSTRACT
ObjectiveTo investigate the expression of urotensin Ⅱ(UⅡ) in the lung cancer tissue from surgical resection of lung cancer patients,and to detect the relationship between UⅡ expression and pathologie types and the clinical stages of lung cancer.MethodsThe expression rates of UⅡof 45 lung cancer tissues and 20 inflammatory pseudotumor were measured by immunohistochemical assay,and the relationship between UⅡ expression and the pathologic types and clinical stages of lung cancer was analyzed.ResultsUⅡwas mainly distributed in lung cancer cell cytoplasm,which was tan-yellow particles.The positive expression rate of UⅡin nonsmall cell lung cancer was 61.3% (19/31),which was higher than that in small cell lung cancer(7.1%,1/14)and pulmonary inflammatory pseudotumor( 15.0%,3/20) (P < 0.01 ).The positive expression rate of UⅡ was 100% in adenocareinoma.The positive expression rate of UⅡin staging Ⅲ non-small cell lung cancer( 85.7% )was higher than that of staging Ⅰ ( 16.7% ) ( P < 0.05).ConclusionUⅡ cxists in the cytoplasm of lung cancer cells,and the expression of UⅡis correlated with the pathological type and TNM staging of lung cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2012
Type:
Article
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