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Effect of Fish Oil-based Intravenous Fat Emulsion with Parenteral Nutrition in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Journal of Clinical Nutrition ; : 29-35, 2016.
Article in Korean | WPRIM | ID: wpr-42082
ABSTRACT

PURPOSE:

Omega-3 fatty acid is known for immunonutrition in that it has anti-inflammatory properties and improves the patients' immune function. The objective of this study was to determine the effects of a fish oil-based lipid emulsion for adult patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).

METHODS:

This was a retrospective study of 90 adult allogeneic HSCT patients from July 2011 to June 2015. The patients were divided into two groups according to the lipid type provided; fish oil group (FO group, n=55) and non-fish oil group (NFO group, n=35). The demographics, parenteral nutrition and lipid emulsion duration, length of hospital stay (LOS), weight change, 30 day mortality, survival period, incidence of acute graft-versus-host disease (aGVHD), neutropenic fever, sepsis, and re-hospitalization were collected from the electronic medical records.

RESULTS:

The patients' characteristics including age, sex, body mass index, and underlying disease were similar in the two groups. The incidence of aGVHD and infectious complications, mortality, LOS, re-hospitalization were also similar. The FO group showed weight gains, whereas the NFO group showed weight loss (FO vs. NFO=0.34% vs. -1.08%, P=0.245).

CONCLUSION:

The clinical outcomes were similar in the two groups but there was a tendency for gain weight in the FO group. A large, well designed study, and a dosing study will also be needed to determine the optimal dose range for HSCT patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Fish Oils / Hematopoietic Stem Cells / Weight Gain / Weight Loss / Body Mass Index / Demography / Incidence / Retrospective Studies / Mortality / Parenteral Nutrition Type of study: Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Humans Language: Korean Journal: Journal of Clinical Nutrition Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Fish Oils / Hematopoietic Stem Cells / Weight Gain / Weight Loss / Body Mass Index / Demography / Incidence / Retrospective Studies / Mortality / Parenteral Nutrition Type of study: Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Humans Language: Korean Journal: Journal of Clinical Nutrition Year: 2016 Type: Article