The factors predicting early efficacy of intravenous thrombolysis with atleplase in acute ischemic stroke / 中华内科杂志

ABSTRACT

Objective To analyze the factors affecting on early efficacy of intravenous thrombolysis with atleplase.Methods The clinical data of 100 acute cerebral infarction patients treated by intravenous thrombolysis with atleplase were retrospectively analyzed.The patients were divided into early effective group and ineffective group,whieh assessed by National Institute of Health Stroke Scale (NIHSS) with criteria of whether there were ＞ 3 or not at 24 hours after therapy.Univariate analysis and multivariate logistic regression analysis were used to determine the differences of clinical data between the two groups.Results Univariate analysis revealed that the early improvement was significantly associated with favorable outcome at 3 month (P =0.000).Multivariate logistic analysis revealed that the systolic pressure at baseline was moderately positively associated with early improvement (OR 1.031,95％ CI 1.008-1.056,P =0.009).Conclusion Moderately lower baseline systolic pressure is associated with early improvement after thrombolytic therapy which is associated with favorable outcome at 3 month.