Study on MICA/B gene polymorphism in northern Hunan Han population / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 785-791, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-420990
ABSTRACT
Objective To study on the characterization of MICA/B genetic polymorphism in a northern Chinese Hunan Han population.Methods Ninty-five unrelated individuals were involved in this study and MICA/B genotypes were determined by two methods:
PCR-sequence-specific primers (PCR-SSP) and PCR-sequence-based typing (PCR-SBT).Results In northern Hunan Han population,eleven MICA alleles were found,among which MICA * 010 (28.95%),MICA * 008 ∶ 01 (20.53%) and MICA * 002 ∶ 01 (15.79%) were the common alleles.Five MICA-STR(short tandem repeat) alleles were found,among which MICA * A5 (37.89%) and MICA * A5.1 (21.05%) predominated.In this population,ten MICB alleles were found.The common alleles were MICB * 005 ∶ 02/* 010 (58.42%),MICB * 002 ∶ 01 (10.00%),and MICB * 008 (7.89%).Two kinds of MICA-MICB haplotypes were MICA * 004-MICB * 004 ∶ 01 and MICA * 010-MICB * 005 ∶ 02/010 in significant linkage disequilibrium.This study also showed MICA/B gene with high polymorphism in different populations.Conclusion MICA/B alleles distribution in northern Hunan Han population with its unique characteristics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2012
Type:
Article
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