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Expression and significance of bcl-2 protein in esophageal squamous cell cancer and the surrounding tissues / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 622-624, 2012.
Article in Chinese | WPRIM | ID: wpr-421091
Responsible library: WPRO
ABSTRACT
Objective To study the expression and significance of bcl-2 protein in esophageal squamous cell cancer and the surrounding tissues.Methods EnVision method was used to analyze the expression of bcl-2 protein in tissues of esophageal squamous cell cancer and the surrounding tissues from 62 patients.Results Expressions rates of bcl-2 protein were 80.3 % (49/61),45.9 % (28/61) and 67.7 % (20/62) in simple hyperplasia,high grade intraepithelial neoplasia and squamous cell carcinoma tissues,respectively,but 3.3 % (1/30) in normal mucosa tissue.There were significant differences between normal esophageal mucosa group and other groups (x2 =54.437,P < 0.01).The expression of bcl-2 had no differentiation in tissue differentiation grade and degree of invasion of carcinoma (x2 =0.219,x2 =5.878,P > 0.05).But it had significant relationship between the expression of bcl-2 and lymph node metastasis (x2 =4.120,P < 0.05).Conclusion bcl-2 may predicting the occurrence of esophageal squamous cell cancer in early stage,and may be regarded as an useful index for prognosis.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Cancer Research and Clinic Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Cancer Research and Clinic Year: 2012 Type: Article